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Spider lamb syndrome
Spider lamb syndrome, also known as spider syndrome〔(Hereditary chondrodysplasia ("spider syndrome") in a New Zealand Suffolk lamb of American origin. ), originally published in ''New Zealand veterinary journal'', Volume 43, p.118-22 (1995); by West, DM; Burbidge, H M; Vermunt, J J; Arthur, D G; archived at the International Sheep Research Centre; retrieved July 19, 2012〕 and more formally as ovine hereditary chondrodysplasia,〔(Developmental progression of the Spider Lamb Syndrome ) in ''Small Ruminant Research'', Volume 18, Issue 2 , Pages 179-184, October 1995, by A.M. Oberbauer, N.E. East, R. Pool, J.D. Rowe, and R.H. BonDurant〕 is a homozygous recessive disorder affecting the growth of cartilage and bone in sheep. It is a semilethal trait,〔(Spider Lamb Syndrome: Introduction ) at UC Davis School of Veterinary Medicine; retrieved July 19, 2012〕 which is thought to have been first observed in the 1970s,〔(Spider Lamb Syndrome - 1998 Sheep Day Report: The Test for Spider Lamb Syndrome Gene in Sheep ) at North Dakota State University; by Bert Moore, Wes Limesand and Paul Berg; publisher 1998; retrieved July 19, 2012〕 and is most common in sheep of the Suffolk and Hampshire breeds.〔(Spider Lamb Syndrome ), at the Merck Veterinary Manual; published 2011; retrieved July 19, 2012〕 The mutation which causes spider lamb syndrome is found on Ovine Chromosome 6,〔(Localization of the locus causing Spider Lamb Syndrome to the distal end of ovine Chromosome 6 ), from ''Mammalian Genome'' 10, 35–38 (1999); by N.E. Cockett,T.L. Shay, J.E. Beever, D. Nielsen, J. Albretsen, M. Georges, K. Peterson, A. Stephens, W. Vernon, O. Timofeevskaia, S. South, J. Mork, A. Maciulis, T.D. Bunch; archived at the University of Liège; retrieved July 19, 2012〕 and involves the inactivation of fibroblast growth factor receptor 3.〔(Enhanced skeletal growth of sheep heterozygous for an inactivated fibroblast growth factor receptor 3 ), ''Journal of Animal Science'', vol. 84 no. 11 2942-2949; by L. B. Smith, M. R. Dally, R. D. Sainz, K. L. Rodrigue and A. M. Oberbauer〕
Afflicted animals may be visibly deformed at birth and unable to stand, or seemingly normal for the first 4 to 6 weeks of their life.〔
The name derives from the limbs of afflicted animals being thin, elongated, and "spider-like".〔(A Novel Mutation in ''FGFR3'' Causes Camptodactyly, Tall Stature, and Hearing Loss (CATSHL) Syndrome ), Am J Hum Genet. 2006 November; 79(5): 935–941; published online 2006 September 26; by Reha M. Toydemir, Anna E. Brassington, Pınar Bayrak-Toydemir, Patrycja A. Krakowiak, Lynn B. Jorde, Frank G. Whitby, Nicola Longo, David H. Viskochil, John C. Carey, and Michael J. Bamshad〕
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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